(Work in progress:) Fibromyalgia References: Symptoms, triggers, treatments etc. intertwined

Deepening on the Symptoms lists: 100, 200, full… ("64"):

Reformulating our experiences is helpful, but I also need to bundle all I find out, for quicker reference. Linking all items/descriptions isn’t possible, but I’ll refer between them and hyperlink to any in-depth-posts. I’ll edit the 3 posts for the month it is possible, then add new versions.

Trigger list (work in progress)

A. Triggers in the sense of general beginning of the disease (pathogenesis)

Study on Fibromyalgia and cytokines" 2014

Current evidence suggests that cytokines and especially chemokines may have a role in the pathogenesis of this syndrome. Cytokines are small soluble factors that work as immune system messengers. They can be classified as pro-inflammatory and anti-inflammatory cytokines. Chemokines are a special kind of pro-inflammatory cytokines that guide the movement of circulating mononuclear cells to the injured side. Some pro-inflammatory cytokine levels (i.e. IL-1RA, IL-6, and IL-8) and, recently, some chemokines’ levels have been found to be increased in patients with fibromyalgia. Thus, herein we review the current knowledge regarding the role of cytokines in fibromyalgia patients and their possible clinical relevance.
“Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37”: Mast cells are involved in FM by releasing proinflammatory cytokines, chemokines, chemical mediators, and PGD2. Ah, I’d heard of mast cells before.
Interesting to me cos of my whole-body cryotherapy is this one: Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles" - very new: Adv Rheumatol. 2021 Jan 13;61(1):3.

Also wondering if GABA and its derivatives are related to this, cf. the updated GABA-thread

B. Triggers in the sense of possible general starting points of fibromyalgia

C. Triggers in the sense of more long-term flares

  • Cold weather

D. Triggers in the sense of day to day flares

  • Overdoing it
  • Stress

Version

Starting 2021-04-16, April 16th. - Delete after starting a new post.

Symptom list (work in progress)

Starting point: 200+ Symptoms of Fibromyalgia (Hard to Believe). What are Yours? - Fibromyalgia Resources from the thread Symptoms lists: 100, 200, full... ("64")

200+ List being changed to alphabetical, ordered by body parts, leaving out repetitions, things I've not heard of much or which are much too specific (e.g. everything "cognitive"!) and ordering things more sensibly (most important word first...)

GENERAL *
Activity level significantly decreased
Raynaud: Cold hands and feet (extremities)
Fibro-Fog: Delayed reaction to physical activity or stressful events
Dryness of eyes and/or mouth
Edema
Trigger: Family member(s) with Fibromyalgia
Fatigue from physical exertion or stress
Feeling cold
Feeling hot
Frequent sighing

Hoarseness
Thirst increased
Raynaud: Poor circulation in hands/feet
Flu-feeling
Shortness of breath with little or no exertion (esp. arms)
Sore throat
Swollen-feeling
Sweats
Triggers: Stress, temperature changes
Lymph nodes swollen, especially in neck and underarms
Trembling, tremor
Weight gain or loss, unexplained

PAIN - Parts of the body, toe to top
Legs:
Feet - Plantar arch or heel pain
Thighs
Restless Leg Syndrome, RLS
RLS
Hip

Torso:
Abdomen/belly
Chest
Ribs - Inflamed Rib Cartilage, Costochondritis
Costochondritis, Ribs
Breasts, lumpy & tender
Clavicula/collarbone
Collarbone/clavicula

Arms: Elbow

Head:
Jaw: TMJ syndrome
TMJ syndrome: jaw
Teeth
Head - Headache
Scalp Pain (like hair being pulled out)

All over:
Joint pain
Nerves burning
Morning stiffness
Stiffness, morning
Stiffness, all day after not moving for a while
Muscle pain
Muscle spasms
Muscle twitching
Muscle weakness
?Pain that ranges from moderate to severe
Pain that moves around the body
Paralysis or severe weakness of an arm or leg
Sciatica-like pain
Tender points (not the same as trigger points)
Trigger points (not the same as tender points)
Voodoo Doll-Poking Sensation in random places

NEUROLOGICAL
Brain fog
Carpal Tunnel
Feeling spaced out
Smells hallucinations
Thinking unclearl
Light-headedness
Noise intolerance
Numbness or tingling sensations
Photophobia (sensitivity to light)
Light sensitivity
Seizures and Seizure-like episodes
Tinnitus (ringing in one or both ears)
Vertigo or dizziness
EQUILIBRIUM/PERCEPTION
Bumping into things
Walking clumsily
Balancing difficult
Distance-judging difficult (when driving, etc.)
Directional disorientation
Dropping things frequently
Disoriented spatially feeling
Tripping or stumbling frequently
Stumbling, tripping frequently
Not seeing what you’re looking at
Balance and coordination poor
Staggering gait

Fatigue at daytime

SLEEP
Alertness/energy best late at night
Sleep/wake schedule altered
Awakening frequently
Falling asleep difficult
Staying asleep difficult
Excessive sleeping, Hypersomnia
Hypersomnia, Excessive sleeping
Narcolepsy
Falling asleep at random and sometimes dangerous moments
Sleep pattern light or broken
Muscle spasms/twitches at night
Sleep disturbances * 104. Sleep starts or falling sensations * 105. Teeth grinding * 106. Tossing and turning * 107. Un-refreshing or non-restorative sleep * 108. Vivid or disturbing dreams/nightmares EYES/VISION * 109. Blind spots in vision * 110. Eye pain * 111. Difficulty switching focus from one thing to another * 112. Frequent changes in ability to see well * 113. Night driving difficulty * 114. Occasional Blurry vision * 115. Poor night vision * 116. Rapidly worsening vision * 117. Vision changes COGNITIVE * 118. Becoming lost in familiar locations when driving * 119. Confusion * 120. Difficulty expressing ideas in words * 121. Difficulty following conversation (especially if background noise present) * 122. Difficulty following directions while driving * 123. Difficulty following oral instructions * 124. Difficulty following written instructions * 125. Difficulty making decisions * 126. Difficulty moving your mouth to speak * 127. Difficulty paying attention * 128. Difficulty putting ideas together to form a complete picture * 129. Difficulty putting tasks or things in proper sequence * 130. Difficulty recognizing faces * 131. Difficulty speaking known words * 132. Difficulty remembering names of objects * 133. Difficulty remembering names of people * 134. Difficulty understanding what you read * 135. Difficulty with long-term memory * 136. Difficulty with simple calculations * 137. Difficulty with short-term memory * 138. Easily distracted during a task * 139. Dyslexia-type symptoms occasionally * 140. Feeling too disoriented to drive * 141. Forgetting how to do routine things * 142. Impaired ability to concentrate * 143. Inability to recognize familiar surroundings * 144. Losing track in the middle of a task (remembering what to do next) * 145. Losing your train of thought in the middle of a sentence * 146. Loss of ability to distinguish some colors * 147. Poor judgment * 148. Short term memory impairment * 149. Slowed speech * 150. Staring into space trying to think * 151. Stuttering; stammering * 152. Switching left and right * 153. Transposition (reversal) of numbers, words and/or letters when you speak * 154. Transposition (reversal) of numbers, words and/or letters when you write * 155. Trouble concentrating * 156. Using the wrong word * 157. Word-finding difficulty Fibromyalgia Disability Car bumper sticker: Lets put this sticker on your car and spread the fibromyalgia awareness. As many people out there don’t consider our illness as being disable, because they don’t know it. *– Click Here to get Yours Fibromyalgia Disability Sticker for you Car * Click Here to visit the store for More Products EMOTIONAL * 158. Abrupt and/or unpredictable mood swings * 159. Anger outbursts * 160. Anxiety or fear when there is no obvious cause * 161. Attacks of uncontrollable rage * 162. Decreased appetite * 163. Depressed mood * 164. Feeling helpless and/or hopeless * 165. Fear of someone knocking on the door * 166. Fear of telephone ringing * 167. Feeling worthless * 168. Frequent crying * 169. Heightened awareness – of symptoms * 170. Inability to enjoy previously enjoyed activities * 171. Irrational fears * 172. Irritability * 173. Overreaction * 174. Panic attacks * 175. Personality changes –usually a worsening of pervious condition * 176. Phobias * 177. Suicide attempts * 178. Suicidal thoughts * 179. Tendency to cry easily GASTROINTESTINAL * 180. Abdominal cramps * 181. Bloating * 182. Decreased appetite * 183. Food cravings * 184. Frequent constipation * 185. Frequent diarrhea * 186. Gerd-like Symptoms * 187. Heartburn * 188. Increased appetite * 189. Intestinal gas * 190. Irritable bladder * 191. Irritable bowel syndrome * 192. Nausea * 193. Regurgitation * 194. Stomachache * 195. Vomiting * 196. Weight gain * 197. Weight loss UROGENITAL * 198. Decreased libido (sex drive) * 199. Endometriosis * 200. Frequent urination * 201. Impotence * 202. Menstrual problems * 203. Painful urination or bladder pain * 204. Pelvic pain * 205. Prostate pain * 206. Worsening of (or severe) premenstrual syndrome (PMS) * * SENSITIVITIES * 207. Alcohol intolerance * 208. Allodynia (hypersensitive to touch) * 209. Alteration of taste, smell, and/or hearing * 210. Sensitivity to chemicals in cleaning products, perfumes, etc. * 211. Sensitivities to foods * 212. Sensitivity to light * 213. Sensitivity to mold * 214. Sensitivity to noise * 215. Sensitivity to odors * 216. Sensitivity to yeast (getting yeast infections frequently on skin, etc.) * 217. Sensory overload * 218. Sensitivity to pressure & humidity changes * 219. Sensitivity to extreme temperature changes * 220. Vulvodynia SKIN * 221. Able to “write” on skin with finger * 222. Bruising easily * 223. Bumps and lumps * 224. Eczema or psoriasis * 225. Hot/dry skin * 226. Ingrown hairs * 227. Itchy/Irritable skin * 228. Mottled skin * 229. Rashes or sores * 230. Scarring easily * 231. Sensitivity to the sun * 232. Skin suddenly turns bright red Cardiovascular (Heart) 234. Fluttery heartbeat * 235. Heart palpitations * 236. Irregular heartbeat * 237. Loud pulse in ear * 238. Pain that mimics heart attack * 239. Rapid heartbeat HAIR/NAILS * 240. Dull, listless hair * 241. Heavy and splitting cuticles * 242. Irritated nail beds * 243. Nails that curve under * 244. Pronounced nail ridges * 245. Temporary hair loss OTHER * 246. Canker sores * 247. Dental problems * 248. Disk Degeneration * 249. Hemorrhoids * 250. Nose bleeds * 251. Periodontal (gum) disease
Touching pain = allodynia
Amplified pain = hyperalgesia
Neck pain: Epsom salt-baths (magnesium sulfate)
Back pain: Epsom salt-baths (magnesium sulfate)
Back pain (lower back, SI-joint, sacro-ilial joint, coccyx, from sitting): Standing work station; lying down with laptop when possible; Yoga exercises for the lower back; back exercises; osteopathy; acupressure; kneeling chair & gym ball if coccyx is OK, chiropractor, special cushions.
Overstraining something: Twist-stretch: stop whatever & twist limbs, back or neck gently & hold it for 10 to 20 seconds.

The following symptom, dry eyes, is an example of just one "side-"symptom with about 15 characteristics, 20 causes/triggers and 20 treatments (just from 2 sites…). Most causes and treatments are very specific. Wind however also triggers core symptoms for me. Whilst such connections may be interesting & helpful they wdn’t generally justify a databank-overload. Maybe it’d make sense to sort symptoms.

Dry eyes: itchiness, hurting, stinging, burning, scratchy, stringy mucus, light sensitivity, eye redness, foreign-body sensation, contact lense difficulty, nighttime driving difficulty, watery eyes (as response), blurred vision, eye fatigue…
**

Dry eyes: 15 treatments:

What Is Dry Eye Syndrome? – Optometrists.org
Warming by cupping warm hands, then Gua Sha, gently.
Dry eyes - Diagnosis and treatment - Mayo Clinic Various therapies, 4 drop types, other things like intense-pulsed light therapy followed by massage of the eyelids, adding omega-3 fatty acids (flaxseed oil, castor oil eyedrops and acupuncture:

Dry eyes: 10s of triggers

Heating, wind,
Dry eyes - Symptoms and causes - Mayo Clinic

Example of a symptom-group, ALSO an image to explain to others, like “run over by a truck/car/train/rhino” or “lead suit”…
Flu-like feeling: heaviness, Ache, fatigue, more pains, rest need, sleep need, sleep long. With or without fever-feeling, sinuses/runny nose (allergy?), headaches (migraines).


Version

Starting 2021-04-16, April 16th. - Delete after starting a new post.

Treatment list

Ordered systematically here first, alphabetically later.
Docs/therapists: If you’re dissatisfied & can afford to do so: change, get 2nd/3rd opinions.

A. MIND (pacing, memes, psychotherapy/CBT, relaxation, sleep)

Psychologist, psychiatrist, psychotherapist, counsellor, pastor, helpdesk, outreach clinic…

A.1. Pacing: Fatigue,

= finding the invisibly moving sweet spots of each activity.
Not trying to keep up with before or others, but keeping under limits, learning what overdoing is.
(Incl. Socializing reduced, esp. evenings: Fatigue)
(incl. Changing work stress and work amount, perhaps work type or work altogether)
Various diaries keeping track of what you’ve done and how you’re feeling before, during & after, adapting with abbreviations to your need, cf. JayCS’s Fibro Blog (see summary-thread ∑)

A.2. Memes = mental hygiene

Pics & Memes that visualize fibromyalgia and other chronic pain illnesses - #91 by AussieMom (German: “Psychohygiene”)

A.3. psychotherapy

e.g. CBT, psychoanalysis

A.3.1. CBT (& b. CPT)

CBT (and A3.1b CPT): Trauma therapy (CPT) for PTSD, Anxiety therapy, depression, with or better without using meds, cf. E1. Biochemical: meds.

A3.2 counseling

x

A.4. Relaxation techniques

Autogenous/autogenic training
self-hypnosis
progressive muscle relaxation (Jacobsen),
Alexander technique…
Calming music
Calming nature sounds
meditation
Reading: stress.
Sun! :sun_with_face:

A.5. Sleep hygiene

Napping is usually not recommended, but try it or power naps and compare.
Get ruminating down: Cut off thoughts with “Stop!” Scissors, Chainsaw, Cold showering
Nightmares: Reality check, reverse imaging techniques…
Sleep diary


B. PHYSICAL/BODY (Hands, Heat/Cold, Devices, Electricity, Do vs. Get Done...)

TCM doctors: acupuncturist, Chinese herbs/teas,
physiotherapists: massage therapist, acupressurist, acupuncturist, osteopath, teachers of the various types of yoga, tai chi, qi gong.
Good physiotherapists are more important than good docs, unless you want mainly meds.

By therapist:…
By yourself:…

Asian or Asian-influenced:...

Acupressure
Ear-acupressure (Penzel)
Acupressure points
palpation points
trigger points
Acupuncture
Ear-acupuncture
Dry needling (trigger point dry needling) Dry needling - Wikipedia
Qi Gong
Tai Chi
TCM
Wim Hof Method, WHM
Yoga types
Breathing exercises
Breathing/breath-holding exercise (Wim Hof)

Breathing exercises
Breathing/breath-holding exercise (Wim Hof)
Nose strips for better breathing, more oxygen
Cold/Heat
Cryotherapy
Whole Body Cryotherapy: Cold Chamber/Barrel (-120°C, now -150°C (-240°F) for 3 mins.
Cold showers (inspired by Wim Hof)
Hand heat baths: canola seed: 15’ (5’)
Hand heat baths: Spelt
Hand cold baths: canola seed: 15’ (5’)
Hand cold baths: Spelt
Sun! :sun_with_face:
Connective tissue massage
Cupping
Electrotherapy
TENS unit or gentler: microcurrent unit (relaxes breathing)
microcurrent unit gentler than a TENS unit
Hydrotherapy: moving in water, using hot or cold water etc.
Water therapy, hydrotherapy
Massages various
Manual therapy
Manipulation
Mechanical devices such as traction.
Mechanical devices:
Traction.
Myofascial massage
Osteopathy
Physical therapy exercises
Body parts
Hand exercises
Neck exercises
Back exercises
Back exercises (“yoga“)
Qi Gong
Stretching - pain, nausea and cramps if longer than 30’’
Tai Chi
TENS unit or gentler: microcurrent unit (relaxes breathing)
microcurrent unit gentler than a TENS unit
Wim Hof Method, WHM
Yoga types
Back exercises
Yin yoga
Changing positions regularly
Standing working station (bar stool, bar table)
Lying down

Sports:

Aqua jogging / Hydrotherapy
Swimming: stress.
Walks: stress
Workout: Muscles, tendons, fascies, joints, breathing, overall.

Stretching, gently!: back pain.
Stretching, gently!: back pain.
Twist-Stretching

Hygiene
Dental hygiene
/Tooth hygiene
Teeth brushing
Teeth flossing
Showering
Washing

(Bioresonance therapy - whatever you think of it…)


C. BIOLOGICAL (Diets, essential oils...)

functional medicine doc, nutritionist, alternative practitioner, allergologist, nutritionist…

Baths cf. Biochemical: supps (magnesium/Epsom salts) and Physical: cold/heat
Cold/Heat cf. Physical: cold/heat
Essential Oils:
Lavender
Swiss pine
Diets:
For Bladder:
For Gut / IBSD/C:
For Stomach:
gluten free diet
low carb diet
Keto diet
paleo diet
Mediterranean diet
Unsaturated fats rather than saturated fats
Complex carbs rather than simple carbs
Omega 3: flaxseed oil
ozone-autohemotherapy (ozone-injections)
oxygen-autohemotherapy (oxygen-injections)


D. ENVIRONMENTAL (Bed, air, cold, heating, light, noises, wind, sun...)

forums, web pages, empathetic doc, counsellor, friends, family, partner

Air rooms
Bed new: pillow: neck pain.
Bed new: mattress: back pain.
Bed new: pillow: neck pain.
Bed new: mattress: back pain.
Pillow under hunchback
Pillow-wedge under face
Place more pillows for comfort
Weighted blankets
Heating - moisten air, but not too much.
cf. Better sleep - 30 wakers & stoppers
Change clothes, blankets
Sun! :sun_with_face: - but carefully…
Wind protection: Hoodies,
Cold protection: Longjohns, rain legs for bike, more socks, more clothes, layered onion-like.
Rain protection: Rain legs for bike


E. BIOCHEMICAL (Meds, supps, herbs)
E1. MEDS

Doctors (change them if necessary, get 2nd and 3rd opinions if you’re dissatisfied and can afford to do so), GP / PCP / principal; pain doctor, rheumatologist (orthopedists), neurologist…

GABA (cf. supps ) & Co.: gabapentin, pregabalin, phenibut, baclofen, picamilon, mirogabalin

GABA & derivatives, gabapentin (Neurontin), pregabalin (Lyrica), phenibut, baclofen, picamilon - #6 by JayCS

Low-Dose Naltrexone, LDN

General: Low-dose naltrexone - Wikipedia
Experiences: Low Dose Naltrexone/LDN for Fibromyalgia: Four Year Update - Melissa vs Fibromyalgia
Side effects: Naltrexone (Oral Route) Side Effects - Mayo Clinic Vivid dreams, IBS
Side effects What are the Side Effects of LDN - Town & Country Compounding
Studies:
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia - PubMed 2017
Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study - PubMed 2009 10 women. may be effective, highly tolerable, and inexpensive.
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review - PubMed 2020 pain. anti-inflammatory and immunomodulator. most studies, incl. for orofacial pain.
The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia - PubMed 2018 4.5mg 25 women
Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships - PubMed 2020 CFS: 3 cases
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients - PubMed IBD 2018: reducing mucosal ER stress
Low-dose naltrexone as a treatment for chronic fatigue syndrome - PubMed CFS 2020
Low-dose naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels - PubMed 2013 31 women pain/mood better, not fatigue/sleep.
The Use of Low-Dose Naltrexone for Chronic Pain - PubMed 2019 pain: could be a viable treatment option cos minimal adverse effects and cheap.
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes - PubMed 2019 pain: increased levels of endogenous opioid production, known as opioid rebound effect
Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy - PubMed 2018 immune review: may become a promising immunomodulatory agent
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PubMed 2014 anti-inflammatory/pain: glial cell modulator.
Low Dose Naltrexone in the Treatment of Fibromyalgia - PubMed 2018: small: safe, likely
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review - PubMed 2018 pain: promising
The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders - PubMed 2018 pain incl. FMS: safe, but unproven
Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization - PubMed 2018 = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313374/ overview: FMS too small.

Celecoxib (Cox-2-inhibitor),
Etoricoxib (Cox-2-inhibitor),
Tilidine (opioid)
Cox-2-inhibitors: Celecoxib, Etoricoxib
Opioids: Tilidine,
Metamizole (“Novalgin”)
Diclofenac
amitriptyline: Helped getting back to sleep for a few months, but too harmful (8 side effects).
Meds: sleep.
Meds: pain.
Venlafaxine ‘Effexor’ SNRI: depression, anxiety, pain.
Milnacipran (trade names Ixel , Savella , Dalcipran , Toledomin), SNRI: fibromyalgia, depression.
Fluoxetine (Prozac) (SSRI): depression, OCD…
Neural therapy - injections with procaine (Local anaesthetic) (Huneke) (complementary medicine)
Hyaluronic acid injections in the lumbar spine - ‘sunburn’ in face, excrutiaing pain in spine
Zomoph
Metoxican
Paracetamol

E2. SUPPS

functional medicine doc, alternative medicine doc, ‘environmental doc’…, some half-conventional docs etc., alternative health practicioner, nutritionist

GABA & Co.: gabapentin, pregabalin, phenibut, baclofen, picamilon, mirogabalin

GABA & derivatives, gabapentin (Neurontin), pregabalin (Lyrica), phenibut, baclofen, picamilon - #6 by JayCS
For sleep. - My GABA side effects initially: tingling, belly ache, all the time: dry mouth, vivid dreams, nose clot, nose bleed, improved after a few days. Positive: Energy, better sleep, less sensitive bladder.
GABA Neurotransmitters as food supplements: the effects of GABA on brain and behavior - PubMed Unclear if and how it works.
GABA in food: A List of Foods with the Highest GABA | Livestrong.com
Gabapentin: epilepsy, neuralgia - Needs 1-2 weeks to develop it’s effect. Side-effects: Increases tiredness.
A List of Foods with the Highest GABA | Livestrong.com

Serrapeptase

A proteoloytic enzyme which users say is anti-inflammatory and has hardly any/no side effects.
Fibro occasionally listed. Altho we of course don’t know if it really has something inflammatory or autoimmune.
Evidence-based medicine seems to believe there are not enough trials to warrant interest.
But a look on pubmed shows a negative review of this kind from 2013, however 3 more positive ones from 2017 2x and 2020.
The role of serratiopeptidase in the resolution of inflammation - PubMed The role of serratiopeptidase in the resolution of inflammation, Asian J Pharm Sci. 2017 May
Serratiopeptidase: Insights into the therapeutic applications - PubMed Serratiopeptidase: a systematic review of the existing evidence. Int J Surg. 2013;11(3):209-17
Analytical techniques for serratiopeptidase: A review - PubMed Analytical techniques for serratiopeptidase: A review J Pharm Anal. 2017 Aug;7(4):203-207
So I am inclined to try it one day, after GABA is helping so well at the moment.
And the feverish-feeling I still get makes me feel there is some hidden inflammation or something autoimmune going on in my body unbeknownst to man. ;o)
3 trusted online pharmacies offer it here, not that cheap tho: 40c per 500mg pill.
Oh, wait a minute: https://draxe.com/nutrition/serrapeptase/
serrapeptase: digestive upset, skin inflammation, infections or rash, can lead to muscle aches and joint pain, risk for pneumonia, infections, bleeding and bruising.

•	Digestive upset, including nausea
•	Skin inflammation and spreading of infections or rash (13)
•	Muscle aches and joint pain
•	Increased risk for pneumonia
•	Potentially increased risk for infections, such as bladder infection
•	Potentially increased risk for bleeding and bruising, especially when combined with drugs such as warfarin, clopidogrel and aspirin

10mg-60, most often 15-30, 5mg for mild symptoms.
Empty stomach, first thing, between meals, 2h from meal.
https://serrapeptase.info/

Good German link on serrapeptase

https://www.foodgroove.de/serrapeptase/ gut - schmerz, schleim, herz, spermien, Entzündungen - Arthritis, Dermatitis, Gastritis, Colitis, Gelenke, Schwellungen, verhindert Aussonderung bestimmter schmerzerzeugender Substanzen z.B. Bradykinin. Hilft bes. lokalisiert z.B. Ohren, Rachen, Nase. Schleim. Blutgerinnsel. Narben. Nattokinase ähnlich, besser gg Alzheimer.
Nicht mit ASS kombinieren.
Nüchtern, 30’-2h vor Mahlzeit, 3x Tal., in Studien meist 10g (-60). Evtll effektiver mit Zn oder Mangan.
Nix in Drogerien, Apo. aber netz.
Studien.

Glutamine
Glutaminic acid
Minerals:

Minerals:
Calcium
Magnesium types:
Epsom salt-baths (magnesium sulfate): neck pain.
Epsom salt-baths (magnesium sulfate): back pain.
magnesium sulfate (Epsom salt-baths): neck pain.
magnesium sulfate (Epsom salt-baths): back pain.
magnesium (taurate) for TMJ
potassium
selene
zinc
proteolytic enzymes for Myofascial and Fibro

Hormones:
(L-)tryptophan
Tryptophan ((L-)tryptophan)
5 HTP
Melatonin: sleep

Melatonin, L-Tryptophan, 5-HTP

Has Anyone Seen the Research on Melatonin? - #16 by JayCS
Shd praps analyze again whether 5-HTP helped in the winter break, as not working in the Easter break did not help:
JayCS’s Fibro Blog (see summary-thread ∑) - #174 by JayCS

progesterone

Vitamins:
Vitamin B12
Vitamin B1
Vitamin B2
Vitamin C
Vitamin E: types
Q10

Omega 3: flaxseed oil, cf. diets.
Regime: Vitamins & mineral regime in 5 phases (Dr. Bodo Kuklinski, Rostock): vitamin b12 injections / potassium, zinc, selene / vitamins B1 + B2, C, E / flaxseed oil / Q10)

E3. HERBS

functional medicine docs, alternative medicine docs, ‘environmental docs’…, some half-conventional docs etc., alternative practitioner

Ashwagandha

Sleep and much more!
Ashwagandha is a nightshade! Who’d’ve thought! Gets on my nerves when such basics are omitted, even on pages like healthline.
Wdn’t keep me off trying it, as I have no detectable problems with at least mild peppers (yellow), but if I feel the need, despite GABA, and the endocrinologist says OK, I’d know where any side effects of it are coming from…

Celafen cream (with Celadrin)

https://selfhacked.com/blog/celadrin/
Celadrin (joint cream) - Wikipedia

Arnica
Arnica oil: pain in muscles and tendons (‘joints’)
Arnica complex cream (‘Traumeel’): pains in muscles & tendons (‘joints’)
CBD oil: sleep.
CBD oil: pain.
Golden root
Passiflora
Rhus toxicodendron
Valeriana
Turmeric, raw peeled: fatigue. (Stomach pain)(German = Curcuma, gelber Ingwer)
Willow bark


Z. My Treatments (JayCS)
Z.1 Helps me, in order of importance:

Acupressure
Whole Body Cryotherapy: Cold Chamber/Barrel (-120°C, now -150°C (-240°F) for 3 mins.
Cold showers (inspired by Wim Hof)
Osteopathy
Breathing/breath-holding exercise (Wim Hof)
Wim Hof Method, WHM
Back exercises (“yoga“)
Connective tissue massage
Autogenous training
Hand exercises
Aqua jogging

Z.2 Harmed me:

Celecoxib (Cox-2-inhibitor),
Etoricoxib (Cox-2-inhibitor),
Tilidine (opioid)
Cox-2-inhibitors: Celecoxib, Etoricoxib
Opioids: Tilidine,
Metamizole (“Novalgin”)
Acupuncture
Neural therapy,
Hyaluronic acid injections in the lumbar spine - ‘sunburn’ in face, excrutiaing pain in spine
Nose strips - allergy if left on nose on too many hours
Stretching - pain, nausea and cramps if longer than 30’’
Cupping
Electrotherapy,
Yin yoga
Physical therapy exercises,
Manual therapy,
Physical therapy: Manual therapy,
Physical therapy: Manipulation,
Manipulation.
Physical therapy: Mechanical devices such as traction,
Mechanical devices:
Traction.
Hand heat baths: canola seed: 15’ (5’)
Hand heat baths: Spelt
Hand cold baths: canola seed: 15’ (5’)
Hand cold baths: Spelt
Qi Gong
Melatonin 2mg extended release and 1mg (halved)
CBD oil 10% 1 drop

Z.3 Didn't help me:

Diclofenac
Willow bark
Glutamine
Arnica
Rhus toxicodendron,
golden root
Magnesium
Calcium
Valeriana,
Passiflora
(L-)tryptophan,
5 HTP,
progesterone,
lavender
Swiss pine,
bioresonance therapy,
gluten free diet,
low carb diet
psychotherapy
Vitamins & minerals: vitamin b12 injections, potassium, zinc, selene, vitamins B1 + B2, C, E, flaxseed oil, Q10)
amitriptyline: Helped getting back to sleep for a few months, but too harmful (8 side effects).
ozone-autohemotherapy (ozone-injections)
oxygen-autohemotherapy (oxygen-injections)
Heavier blanket (haven’t tried a real weighted one yet, but seems to irritate)


Version

Starting 2021-04-16, April 16th. - Delete after starting a new post.

100 studies on fibro per month… :upside_down_face:

I just thought I’d look if there’s a new study or two on pubmed: <fibromyalgia 2021> brings up 394 results. Dud, I thought. Scanned thru them all. Not dud! A few are from 2020. That’s 100 studies per month! Most of them center on fibro, all of them relevant in one way or another (pain, duloxetine etc.).

Examples

Symptoms
Women Fibromyalgia in women: somatisation or stress-evoked, sex-dimorphic neuropathic pain? - PubMed
Stigmatization Fibromyalgia, Chronic Fatigue Syndrome, and Multiple Chemical Sensitivity: Illness Experiences - PubMed
PsA Fibromyalgia in patients with psoriatic arthritis: Relationship with enthesopathy, sleep, fatigue and quality of life - PubMed
Laziness-prejudice "Everyone thinks I am just lazy": Legitimacy narratives of Americans suffering from fibromyalgia - PubMed
Age differences: young - more anxiety; middle - more pain & co-morbidities, old - “better self-report cognitive function” Comorbid Conditions, Mental Health and Cognitive Functions in Adults with Fibromyalgia - PubMed
PsA-co-morbidity worsens Fibromyalgia in patients with psoriatic arthritis: Impact on disease activity indices, fatigue and health-related quality of life - PubMed
Personality is irrelevant Personality and psychopathology heterogeneity in MMPI-2 and health-related features in fibromyalgia patients - PubMed

Causes
SFN Advances in the Management of Small Fiber Neuropathy - PubMed
Salivary Biomarkers Application of Salivary Biomarkers in the Diagnosis of Fibromyalgia - PubMed

Treatments
Pregabalin Pregabalin - PubMed
Exercise Effectiveness of Exercise on Fatigue and Sleep Quality in Fibromyalgia: A Systematic Review and Meta-analysis of Randomized Trials - PubMed
Q10 Coenzyme Q10 - PubMed
Exercises Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis - PubMed
Neural Therapy Neural therapy for fibromyalgia: Myth or improving quality of life? - PubMed
Pain education [Effectiveness of pain neuroscience education in patients with fibromyalgia: Structured group intervention in Primary Care] - PubMed
Therapies don’t help much Association of Therapies With Reduced Pain and Improved Quality of Life in Patients With Fibromyalgia: A Systematic Review and Meta-analysis - PubMed
Medical Cannabis can help, types unclear Safety and Efficacy of Medicinal Cannabis in the Treatment of Fibromyalgia: A Systematic Review - PubMed
Mindfulness & CBT help help Differential efficacy between cognitive-behavioral therapy and mindfulness-based therapies for chronic pain: Systematic review - PubMed
Walking helps Promoting unsupervised walking in women with fibromyalgia: a randomized controlled trial - PubMed