2021-05-29, Saturday - really long deep sleep…
FEELING Well % / Pain 0-7 DOING
Sleep: 90%/1 10h30, up 3x (20’) short breaks , 30’ overexertion yesterday
Activities: 70%/3 h (digi-work h sports 1h10 TT 4:2 shop )
Only just occured to me: Whilst relaxed muscle seem best determining factor for my TT playing (table tennis), I shdnt neglect eye focus, nerve transmission and muscle pre-exertion. Also conversely: if I start needing to overstrain muscles to play better, my muscle relaxation wil soon disappear, even if it was there to start with. Today I doped myself with cold showering, that lasted the 1st 2 games, then lost 2, and the last 2 games, I used muscle pressure. So cold showering again after might help, like it did before. All of course nec. cos of carrying stuff yesterday evening together with the long sleep.
Treatment: 90%/1 1h12 (self) fw: 7h10
Effects of 300mg GABA + 50mg levodopa+25%benserazide, 2x290mg passiflora, minus candesartan (0 Mg):
Long deep sleep, despite problem solving dream: This combo with 300mg instead of 200mg GABA & 2x290mg passiflora added seems to fit, at least at the moment. Head/eyes/heaviness OK today. Candesartan I saw in the blood pressure checks yesterday that it’s right to leave that completely.
Natural L-dopa, e.g. in the Mucuna Pruriens beans, might be even better
Interesting that L-dopa can be found in 2 bean types, most in Mucuna Pruriens and that researchers have studied it to find better alternatives to pure L-dopa with less side effects.
L-Dopa in Arzneipflanzen und deren Anwendung für Parkinsonpatienten – Stand des Wissens – Rosenfluh.ch
GABA can have a paradox effect in higher doses...
Interesting fact here, that too high doses of GABA can cause a paradox effect of worse sleep, anxiety, another reason for having adjusted it lower:
(German link) Gaba -Wirkung, Dosierung, Mangel, Nebenwirkungen -VitaminExpress (used this link before I think, mentions the various combinations etc.)
L-dopa and fibromyalgia? 1) Stiffman syndrome case: L-dopa & GABA! 2) FMS & dopamin-system
A look for L-dopa with fibromyalgia on pubmed: l-dopa fibromyalgia - Search Results - PubMed only yielded
a one-patient study of the very rare Stiffman Syndrome from 1973 Sleep Studies and Therapeutic Trial with L-Dopa in a Case of Stiffman Syndrome - Abstract - European Neurology 1973, Vol. 10, No. 2 - Karger Publishers (Sleep studies and therepeutic trial with L-dopa in a case of Stiffman syndrome - PubMed)
“A possible imbalance between a catecholaminergic and a GABA-ergic system in the Stiffman syndrome is hypothesized.” Interesting for me as my all-day-&-night-stiffness has been decreased to 20% by GABA.
Reduced presynaptic dopamine activity in fibromyalgia syndrome demonstrated with positron emission tomography: a pilot study - PubMed 2007, US. “An association between FMS and reduced dopamine metabolism within the pain neuromatrix provides important insights into the pathophysiology of this mysterious disorder.” - quoted by 77 articles, right up to 2021, of those is slightly interesting:
Canada, 2020 “Sleep and pain” Sleep and pain: recent insights, mechanisms, and future directions in the investigation of this relationship - PubMed.
"Moreover, the possible mechanisms contributing to this relationship as endogenous pain modulation, inflammation, affect, mood and other states, the role of different endogenous substances (dopamine, orexin, melatonin, vitamin D) as well as other lesser known such as cyclic alternating pattern among others, will be explored. Finally, directions for future studies on this area will be discussed, opening up to the addition of tools such as brain imaging (e.g., fMRI), electrophysiology and non-invasive brain stimulation techniques. Such resources paired with artificial intelligence are key to personalized medicine management for patients facing pain and sleep interacting conditions. "
Nutmeg & St. John’s Wort probably don’t help: Herbal medicinal products or preparations for neuropathic pain - PubMed
Feeling/Action-details: Problem solving dreams, 1 realistic, but unsettling, 1 pseudo, strange
(Well in % / Pain incl. Gut 0-10) (Sleep, Fibro-‘Work’, Work Digi & Live, Activity, Treatment)
Sleep 300mg GABA, 6, 22:35- 1:55p 3:45 thirst 7:00 noises 10’ -9:28 = 1h25+9h28-5-5-10= 10h50-20 = 10h30, up 3x (20’).
1:55: Long stint for starters due to preponing 6…? Do I need to think more about how to schedule that? Waking was probably due to pee urge (lots), but not strong, so I need to watch doubly if it is actually usually that and not feeling awake…? Sensitive stuff, ay!
3:45: definitely thirst not pee upon waking. Sore throat → Marigold, but gargling more intensely and deeper (it’s coming from the pharyngeal? tonsils, at least the deeper ones) heating on, warmer socks, keep hot water bottle.
7:05: I’d tried to refrain from using ear plugs, just Continental quilt over my head, so noises were slowly waking me up. Still actually very tired and not enough. 2 problem solving type dreams, but not enlightening: first was due to an - actual - change in work schedule perhaps having to go to get up at 6:20 every day now (which wd be realistic if I wasn’t ill). In the 2nd a new very friendly GP made out 3 problem areas of my symptoms, plus saw that my left thumb had grown completely off, with a sort of graft-type of displacement 20cm down my left underarm - totally unrealistic, can’t see where that came from or is going to…
7:10-7:35 in unsettled problem solving mode, trying to calm myself with AuTr & dozing.
Now go all out to get my last hour of sleep… Lavender & AuTr & self-hypnosis, dry mouth gel.
BTW: When I don’t move at night, I don’t have pains. When I do they are only there for a short time, pains & pins & needles, not like they used to be.
-9:28 whoopsie, must have worked!
11:55 Ache, tired, so trying another cold shower…
Self-treatments: Timing, sore throat 7x2’ (gargling deeper & more vigorously , plus a bit of heating on), gum/tooth, 2x1’, thumbnail 7x1’, AuTr 15’, palpate 2’, belly 6’, back 8’, workout 8’, cold shower (10’) = 72’ , neck 1 ', neck 2 ', yoga ', loins ', marionette-hang ', hunchback hard cushion ', breath-hold ', Achilles ', shaking dance ', blood pressure
Fibro-work: 2:00: 5’ 7:05: 5’ 10:40: 30’ 11:40: 10’ 13:35: 30’ 14:45: 25’ 15:55-20-21:20=5h 21:40: 10’ 22:30: 15’ = 7h10 Oh dear, that’s overdone this! - but it was fun, and didn’t hurt - might do tomorrow tho…
Added & rearranged Fibromyalgia References: Symptoms, triggers, treatments (to be intertwined)
Abbreviations - incl. new ones since May 18th
’ = mins = minutes, ‘’ = secs = seconds, h is hours as time length, 3h is 3 hours long, 3:00 is 3am, 15:00 is 3pm. 18:10:40’ means 40 minutes, starting at 18:10, = 10 minutes past 6pm up to 10 to 7pm
AT = Autogenic Training, cold/FCS = Flash Cold Shower (20’’) , ex = exercises, HWB = Hot water bottle, breath-hold/WHM-B-H = Wim Hof Method Breath-Holding, slp = sleep.
Reasons for getting up w = awake, lbu: lower back unrest (‘RLS’?), p: pee, i: ideas. PsA = Psoriatic Arthritis-suspicion
fw = fibro-work
Pain 7 = crying (/out) point
TT = table tennis, 5:1 = score, usually showing how well I’m feeling: energy, relaxedness & alertness if the first number is much higher than the second.
Cold showering itself only takes 20’’+40’’=1’, but I now count it as 10’.
Neck 1 is stretching in the various directions, neck 2 is pressing my head against my hand “without moving”.
loins = loins/groin = stretching the ligaments there.